Birc5 proliferation

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WebBIRC5 INFORMATION. Proteini. Full gene name according to HGNC. Baculoviral IAP repeat containing 5. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BIRC5 (API4, EPR-1, survivin) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebOct 16, 2024 · Following knockdown of BIRC5, mitochondrial membrane depolarization further sensitized KGN cells to induction of apoptosis via TRAIL. These results indicate an essential role, distinct from metabolism, for mitochondrial membrane potential in KGN cells to sense and respond to external mediators of apoptotic induction. ... proliferation, and ...

JASPAR analysis results for YY1 binding sites located within the ...

WebThe results indicate that KLF2 could suppress BIRC5 expression transcriptionally. CONCLUSION. In summary, the miR-92a-3p/KLF2/BIRC5 regulation axis was identified … WebOct 12, 2024 · More importantly, upon overexpressing BIRC5 in RKO cells with down-regulated RFWD3, the inhibitory effects of cell proliferation, migration and colony formation could be reversed, while the capacity of cell apoptosis was ameliorated, demonstrating the effects of RFWD3 depletion was mainly due to BIRC5 suppression (Figures 5A–E). can i use afterpay at woolworths

miR‐92a‐3p promotes breast cancer proliferation by regulating …

WebMay 11, 2024 · Through rescue experiments, we proved that BIRC5 reversed miR-3940-3p-mediated cell proliferation or apoptosis in BBOX1-AS1-dysregulated GC cells. BBOX1-AS1 accelerates GC proliferation by sponging miR-3940-3p to upregulate BIRC5 expression, which may guide a new direction into the therapeutic strategies of GC. Gastric cancer … WebAug 21, 2024 · Aberrant expression of BIRC5 in various malignancies has been confirmed closely associated with cell cycle, proliferation, migration, immune infiltration, and the … can i use afterpay at costco

Potential Involvement of BIRC5 in Maintaining …

Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

WebAs a mitotic spindle checkpoint gene, baculoviral IAP repeat containing 5 (BIRC5) serves pivotal roles in the development of various types of malignant tumors. In the present … WebDec 12, 2012 · Using BIRC5- or BCL2L1-specific shRNAs (Figure 4SA, B), we found that depletion of BIRC5 or BCL2L1 impaired the proliferation and AI growth of β-catenin-dependent cell lines (Figure 4A, B). These observations corroborate recent observations that cancer cell lines that harbor activating mutations in β-catenin are particularly sensitive to ... can i use afterpay at any storeWebWe found robust expression of Mki67 and other markers of proliferation (Anln, Aurka, Birc5, Pcna, and Plk1) used by Soonpaa et al. in neonatal cardiomyocytes (Fig. 3G), in agreement with our bulk mRNA-sequencing data (Fig. 1F). However, expression of these proliferation markers was largely negligible in adult cardiomyocytes (Fig. 1F). five nights at night

"WebJan 11, 2024 · BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to ... " - Birc5 proliferation

Birc5 proliferation

RETRACTED ARTICLE: BBOX1-AS1 Accelerates Gastric Cancer Proliferation …

WebSep 6, 2024 · The expression of FEN1 in TCGA liver cancer tissues was positively correlated with that of MCM2 (r = 0.853, P = 0.000), BIRC5 (r = 0.809, P = 0.000), and RFC4 (r = 0.852, P = 0.000) (Figs. 6B – 6D), suggesting that FEN1 may play as important a role in the progression of liver cancer as do MCM2, BIRC5, and RFC4. The ONCOMINE … WebMar 3, 2024 · BIRC5 has been shown to play vital roles in carcinogenesis by affect the cell proliferation and by inhibits cell apoptosis (Yamamoto et al., 2008). Since BIRC5 is frequently up-regulated in diverse cancers and treatment that targets BIRC5 has been increasingly noticed as a novel strategy for various malignant tumors ( Jaiswal et al., 2015 ).

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WebMar 21, 2024 · Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, 21364656, ... (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and CDCA8 (PubMed:17956729). … WebMar 21, 2024 · Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, 21364656, ... (CPC) composed of at least …

WebMar 25, 2024 · The BIRC5 (Baculoviral IAP Repeat Containing 5) gene located on chromosome 17 (17q25.3) encodes for the Survivin protein, which is a member of the IAPs (inhibitor of apoptosis family) that is normally expressed in humans during fetal development and in adult proliferating cells [].Survivin is a small protein with different isoforms, the … WebJan 7, 2024 · BIRC5, on the contrary, is commonly considered an anti-apoptotic molecule, promoting cell division and tumor progression and it is widely regarded as potential therapeutic target. ... Importantly, cell proliferation upon genetic disruption is dramatically reduced, as demonstrated by a 90% reduction in radioactive-thymidine incorporation . …

WebNov 14, 2024 · The proliferation gene signature will be based on 11 highly correlated proliferation genes shown in multiple studies including those published by The Cancer Genome Atlas and they also contribute to the calculation of the proliferation score in the publicly available PAM50 classifier. The list consists of: CCNB1, UBE2C, BIRC5, … WebSurvivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. ... In adult organisms, apoptosis is needed to maintain differentiated tissue by striking the balance between proliferation and cell death. It is known that intracellular proteases called caspases ...

WebDec 12, 2024 · Finally, Wnt7B, a specific ligand for FZD5, was shown to be involved in cell proliferation, DNA damage repair, and stemness. ... transcription factor FOXM1, which promoted BRCA1 and BIRC5 ...

WebJul 24, 2024 · Genes in component 2 were mainly related to cell proliferation (e.g., Birc5, Mki67, and Top2a). Cell cycle regression analysis and GSVA scoring revealed a correlation between proliferative ability ... can i use afrin for 4 daysWebJun 19, 2012 · Over-expression of BIRC5 could significantly attenuate the effect of miR-203 on the inhibition of MDA-MB-231 cell proliferation. (A) BIRC5 protein expression was … can i use afrin in my earWebMay 27, 2024 · Further, effect of hnRNPA2B1 on BIRC5 alternative splicing was investigated. We show that overexpression of hnRNPA2B1 in GC is correlated with poor … five nights at nightclub gameWebHuman Gene BIRC5 (ENST00000590449.1) from GENCODE V43 : Description: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an … can i use afterpay for groceriesWebThe results indicate that KLF2 could suppress BIRC5 expression transcriptionally. CONCLUSION. In summary, the miR-92a-3p/KLF2/BIRC5 regulation axis was identified in breast cancer proliferation, which may serve as emerging cancer biomarkers and provide promising strategies for breast cancer therapy. AUTHOR CONTRIBUTIONS five nights at nikocado avocadoWebMar 21, 2024 · In particular, the representative cell proliferation marker (MKI67), proliferative cell nuclear antigen (PCNA), 39 DNA topoisomerase II alpha (TOP2A), a baculoviral inhibitor of apoptosis repeat-containing protein 5 (BIRC5/Survivin), 14 master regulator of cell proliferation, forkhead box M1 (FOXM1), 40 E2F family, 41 and cyclin … can i use afterpay in igaWebThe cancer-specific promoter BIRC5 and non-specific CMV immediately early gene promoter were used for comparison. All cloned promoters were shown to be substantially more active in cancer cells than in fibroblasts, while the PLK1 promoter was the most cancer-specific and promising one. five nights at nintendo land wiki