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WebNumerous studies suggest there are many other effective sedative agents with more predictable pharmacokinetic profiles than chloral hydrate, including oral or intranasal … WebMedically, chloral hydrate acts both as a sedative to calm patients and, with appropriate doses, as a hypnotic, putting the patient to sleep. These effects mean that it has been used in the past to give a sedating effect before surgery, though it has now been replaced by safer and better controlled substances. WebNov 3, 2024 · Chloral hydrate overdose. Chris Nickson. Nov 3, 2024. Home LITFL Clinical Cases. aka Toxicology Conundrum 020. A 25 year-old woman with a history of depression was found by her flatmate. An empty 200mL bottle of chloral hydrate was present at the scene. She arrived at your emergency department with the following vital signs: systcom inc