Cisplatin kidney toxicity

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August undefined, 2024

WebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … WebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also …

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in … bioforce hrv

Determining the Potential of DNA Damage Response (DDR) …

WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer … WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and hematological toxicity … bioforce kenöcs

Cisplatin-induced renal toxicity in elderly people - ZhiYu Duan ...

Cisplatin dose adjustment in patients with renal impairment, …

WebThe nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. WebOct 7, 2024 · 3. Cisplatin Nephrotoxicity. Experimental nephrotoxicity, first reported in 1971 [], is the most frequently studied cisplatin side effect.Over the past decades, researchers have demonstrated that cisplatin can cause nephrotoxicity or acute kidney injury (AKI) of varying severity in a dose-dependent manner [].Depending on the dose (single or … daikin corporationWebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with … daikin cora 7.1kw split system

"WebAug 1, 2024 · Cisplatin can also cause direct nephrotoxicity as it accumulates within the renal epithelial cells leading to DNA damage and release of damage associated molecular patterns (DAMPs). As a consequence, cytokines and inflammatory cells are … " - Cisplatin kidney toxicity

Cisplatin kidney toxicity

Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity - Medscape

WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … WebCisplatin for injection can cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. Renal …

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WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various … WebFeb 1, 1989 · Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. We reviewed clinical and experimental literature on cisplatin...

WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the … WebCisplatin is a potent tubular toxin with a high incidence of nephrotoxicity. Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin.

WebFig. 2: The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA … WebCisplatin can affect the kidneys. You will be given extra fluids through the drip before and after the cisplatin. You may also have a drug called mannitol. The fluids and mannitol can help prevent kidney damage. Your nurse will explain how long this will take. Your course of …

WebCisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after …

WebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... bioforce inkafarma precioWebAbstract Renal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. daikin cora ftxv71wvmaWebJan 7, 2024 · Cisplatin has a well-documented array of toxic side-effects, of which some are potentially irreversible, including nephrotoxicity. 1,2 Accordingly, cisplatin infusion is usually combined with saline to hydrate and mannitol infusion to promote osmotic diuresis to prevent permanent damage to the renal tubules. 2–4 bioforce irvineWebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal … daikin credit ratingWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … daikin ctk04 thermostatWebApr 12, 2024 · Evaluation of the effect of glycine infusions on the early renal uptake of cisplatin. Kidney platinum content was markedly lower in rats who had received glycine infusion compared to control rats who had received saline-infusion. ... Klastersky, J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin … bioforce humanitaireWebMar 2, 2024 · Cisplatin is a potent anticancer drug widely used for the treatment of several malignant tumors. One of the most relevant side effects of cisplatin is nephrotoxicity, that is very well-known since its introduction in 1978 and limits its use and efficacy [ 1, 2 ]. bioforce lid clips