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Son splicing

WebDec 3, 2015 · SON is a poorly characterized nuclear protein that is particularly abundant in hematopoietic cells/organs and embryonic stem cells. This protein was recently identified as an SR-like splicing co-factor required for proper cell cycle progression (Mol. Cell. 2011, 42:185) and maintenance of stem cell pluripotency (Nat. Cell. Biol. 2013, 15:1141). WebThe eukaryotic RNA splicing machinery is dedicated to the daunting task of excising intronic sequences on the many nascent RNA transcripts in a cell, and in doing so facilitates proper translation of its transcriptome. Notably, emerging evidence suggests that RNA splicing may also play direct roles in maintaining genome stability.

REGULATION OF TRANSCRIPT SPLICING BY SON IN EMBRYONIC …

WebOct 1, 2013 · The splicing-associated protein SON is now shown to be necessary for embryonic stem cell maintenance, by influencing the splicing of pluripotency regulators. You have full access to this article ... WebSON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in … northeast houston https://northernrag.com

SON connects the splicing-regulatory network with pluripotency in …

WebMar 21, 2024 · Entrez Gene Summary for SON Gene. This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV … WebSep 21, 2024 · Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 ... WebOct 23, 2024 · The monoclonal antibody SC35, raised against a spliceosomal extract, is frequently used to mark NS. Unexpectedly, we found that this antibody was mischaracterized and the main target of SC35 mAb is SRRM2, a spliceosome-associated protein that sharply localizes to NS. Here we show that, the core of NS is likely formed by … how to return a social security check

Son and Its Alternatively Spliced Isoforms Control MLL Complex …

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Son splicing

Son and Its Alternatively Spliced Isoforms Control MLL

WebDepletion of SON in hESCs results in the loss of pluripotency and cell death. Using genome-wide RNA profiling, we identified transcripts that are regulated by SON. Importantly, we confirmed that SON regulates the proper splicing of transcripts encoding for pluripotency regulators such as OCT4, PRDM14, E4F1 and MED24. WebSep 1, 2014 · SON is a nuclear protein involved in multiple cellular processes including transcription, pre‐messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre‐mRNA splicing as well as the influence of …

Son splicing

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WebApr 30, 2014 · SON is a nuclear protein involved in multiple cellular processes including transcription, pre-messenger RNA (mRNA) splicing, and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON's function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of … WebDec 3, 2015 · SON is a poorly characterized nuclear protein that is particularly abundant in hematopoietic cells/organs and embryonic stem cells. This protein was r…

WebJan 21, 2024 · Pairwise correlation of all features shows modest redundancy but for certain combinations, such as 5’ linear splice (5’S) and 3’ linear splicing (3’S), we find a high level of positive interdependence (Figure 6—figure supplements 1 and 2), whereas intron retention generally correlates negatively with linear splicing (5’IR vs 5’S and 3’IR vs 3’S). SON protein is essential for maintaining the subnuclear organization of the factors that are processed in the nucleus highlighting its direct role in pre-mRNA splicing. Splicing is the process through which pre-mRNA is transformed into mRNA. The pre-mRNA which has just been transcribed contains sequences called introns a…

WebDec 15, 2011 · Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. We recently showed that a large SR protein called Son has unique repeat motifs that are essential for maintaining the subnuclear organization of pre-mRNA processing factors in nuclear speckles. Motif analysis of Son highlights putative RNA … WebMy son showed an interest in what I do, so I showed him how to splice fibre. The only problem is the splicer I had to hand was in need of a service and not a...

WebNational Center for Biotechnology Information

WebSep 8, 2013 · In 2011, it was further shown that SON functioned in pre-mRNA splicing [10,14]. SON also has a role in regulating the pluripotency of human embryonic stem cells [15] and is highly expressed in ... north east hr consultantsWebApr 22, 2011 · Here, we report that SON, a large Ser/Arg (SR)-related protein, is a splicing cofactor contributing to efficient splicing of cell-cycle regulators. Downregulation of SON leads to severe impairment of spindle pole separation, microtubule dynamics, and genome integrity. These molecular defects result from inadequate RNA splicing of a specific set ... northeast houston hearing servicesWebSep 8, 2013 · A splicing-regulatory network is connected for accurate transcript production to the maintenance of pluripotency and self-renewal of hESCs and it is confirmed that SON regulates the proper splicing of transcripts encoding for plurine regulators such as OCT4, PRDM14, E4F1 and MED24. Human embryonic stem cells (hESCs) harbour the ability to … how to return array list in javaWebJan 29, 2014 · In the absence of SON, they discovered that splicing patterns were altered in more than 1,000 different RNA transcripts, including many involved in maintaining ESC pluripotency and self-renewal. how to return array in method javaWebApr 5, 2024 · Quick, simple, stunning. It’s never been faster or easier to edit on the go like a pro. Splice Video Editor: make stunning videos in a snap! + Splice offers the best tools for making videos and movies on mobile. + … northeast hudl flWebJul 1, 2010 · The fact that SON depletion phenocopies spliceosome inhibition, 19, 20 rendering discernible changes in SC-35 focal accumulation , suggests that SON deficiency may hinder processing of pre-mRNAs important for a number of cellular processes. Whether SON modulates or is endowed with RNA splicing activity will require further work. northeast hs philly footballWebApr 30, 2014 · Europe PMC is an archive of life sciences journal literature. north east humanists